Description
CJC-1295 5mg (with DAC) CJC is one of our top selling peptides –CJC-1295 with DAC is a long-acting synthetic analog of growth hormone-releasing hormone (GHRH). The DAC (Drug Affinity Complex) modification binds reversibly to albumin, extending the peptide’s half-life to approximately 6–8 days. By stimulating pituitary GHRH receptors, CJC-1295 DAC increases GH secretion and circulating IGF-1 in a dose-dependent manner. CJC-1295 w/DAC is a peptide that may increase the production of growth hormone (GH) and insulin-like growth factor-1 (IGF-1). It is believed to work by stimulating the liver to produce IGF-1 through the JAK-STAT signaling pathway. Studies suggest that CJC-1295 w/DAC can create a significant and lasting increase in both GH and IGF-1 levels, with effects potentially lasting for several weeks and having a cumulative impact with consistent research. Key Benefits of CJC-1295 w/DAC Aids research into the effects of prolonged GH release Enables longer-duration studies due to a half-life up to 8 days Promotes consistent research outcomes of GH secretion Researchers can study the effects of GH and IGF-1 secretion Investigated for impacts to metabolism and tissue growth/repair Provides a tool for exploring GHRH-R and JAK-STAT signaling Lyophilized format provides consistent outcomes in laboratory settings The Science Behind CJC-1295 w/DAC CJC-1295 w/DAC binds to the GHRH receptors on the anterior pituitary gland located on the surface of somatotropic cells. Upon binding, the receptor undergoes a conformational change that activates a well-defined signaling cascade: The adenylyl cyclase stimulates the enzyme adenylyl cyclase. Adenylyl cyclase catalyzes ATP into cAMP (cyclic adenosine monophosphate). The accumulation of cAMP leads to the activation of cAMP-dependent PKA (Protein Kinase A). PKA adds a phosphate group to activate the CREB phosphorylation process, binding to specific DNA sequences (CREs) located in the GH gene. The CREB binding event initiates the transcription of the GH gene, leading to the synthesis of new GH mRNA and new GH protein. 5 MG Powder
